Cathelicidin antimicrobial peptide : a novel regulator of islet 2 function , islet regeneration and selected gut bacteria 3

Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada 6 Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and 7 Immunology, University of Ottawa, Ottawa, ON, Canada 8 Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, 9 Mansoura, Egypt 10 Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, 11 ON, Canada 12 Department of Medicine, University of Ottawa, Ottawa, ON, Canada 13 14 Running title: Cathelicidin affects islets and gut microbiota 15 Correspondence and requests for materials should be addressed to FWS: 16 ORCC 3 North Wing, Mail Box 221, 501 Smyth Road,Ottawa, ON K1H 8L6, Canada 17 Tel: (613) 737-8929; E-mail: [email protected] 18 19 WORD COUNT: 4,108 20 Page 1 of 35 Diabetes